-2022-

​​

Bioactivity of Boronic Acid Derivative Homodimers

Ota K., Zhou J.-R., Yokomizo K., Kozako T., Honda S., Kashige N., Furutachi M., Sumoto K.,

Results Chem., 4, 100559 (2022).

10.1016/j.rechem.2022.100559

​

Antiviral Activity of Some C3-Symmetrical N-Methyl Benzylamine-Substituted 1,3,5-Triazines and Related Compounds

Shimomura S., Yokomizo K., Zhou J.-R., Mibu N., Furutachi M., Sumoto K.,

Heterocycles, 104, 1845-1853 (2022).

10.3987/COM-22-14706

 

-2021-

​

Hybrid Linker Mode C2-Symmetrical 1,3,5-Triazine Derivatives and Their Biological Evaluation

Shimomura S., Yokomizo K., Zhou J.-R., Ota K., Mibu N., Furutachi M., Sumoto K.,

Heterocycles, 102, 2379-2390 (2021).

10.3987/COM-21-14549

​​

​​

-2020-

​

Some New C3- and Cs-Symmetrical Trialkylamino- Substituted 1,3,5-Triazines and Their Biological Evaluation

Shimomura S., Inoue Y., Kawano Y., Fujita Y., Yamada K., Matsumoto Y., Yokomizo K., Zhou J.-R., Ota K.,

Mibu N., Furutachi M., Sumoto K.,

Heterocycles, 100, 1657-1665 (2020).

10.3987/COM-20-14308

​

​

-2019-

​

Some Hybrid Linker Mode C2-Symmetrical 1,3,5-Triazine Derivatives and Their Biological Evaluation

Mibu N., Furutachi M., Inoue Y., Fujita Y., Matsumoto Y., Kawano Y., Tomonaga S., Matsuyama J., Yamada K., Sato R., Yokomizo K., Zhou J.-R., Shimomura S., Ota K., Sumoto K.,

Heterocycles, 98, 1580-1588 (2019).

10.3987/COM-19-14174

​

Anti-proliferative Activities of Some Bivalent Symmetrical 5-Substituted Hydantoin Derivatives towards

Human Brain Glioma U251 Cells (U251) and Human Carcinoma Cells (KB3-1)

Furutachi M., Ota K., Fujisaki F., Ikeda R., Yoshikawa N., Yokota T., Takeda Y., Yokomizo K., Zhou J.-R.,

Kashige N., Miake F., Sumoto K.,

Biol. Pharm. Bull., 42, 1953-1956 (2019).

10.1248/bpb.b19-00486

​

Anti-proliferative Activities towards Human Brain Glioma U251 Cells and Human Carcinoma Cells (KB3-1) of

Some Twin-Drug Type Bivalent C2-Symmetrical Phenylboronic Acid Derivatives

Furutachi M., Gondo T., Ikeda R., Yoshikawa N., Yokota T., Takeda Y., Yokomizo K., Zhou J.-R., Kashige N.,

Miake F., Sumoto K.,

Biol. Pharm. Bull., 42, 833-836 (2019).

10.1248/bpb.b18-00859

​

Preparation of Some Novel Trisubstituted 1,3,5-Triazines and Hybrid Linker Mode 1,3,5-Triazine Derivatives

and Their Biological Evaluation

Mibu N., Yokomizo K., Yamada K., Matsuyama J., Tomonaga S., Sakai I., Sato R., Kawano Y., Matsumoto Y.,

Fujita Y., Inoue Y., Iida M., Hashiguchi K., Zhou J.-R., Furutachi M., Sumoto K.,

Heterocycles, 98, 489-508 (2019).

10.3987/COM-19-14052

​

Carbohydrate Recognition of C3-Symmetrical Tripodal Receptor-type 2,4,6-Trisubstituted 1,3,5-Triazine

Derivatives with Antiviral Activities

Mibu N., Ohata T., Sano M., Zhou J.-R., Yokomizo K., Aki H., Sumoto K.,

J. Therm. Anal. Calorim., 135, 2807-2811 (2019).

10.1007/s10973-018-7573-4

​​

​​​

-2018-

​

Preparation and Antiviral Activity of Some New C3- and Cs-Symmetrical Tri-substituted Triazine Derivatives

Having Benzylamine Substituents

Mibu N., Yokomizo K., Sano M., Kawaguchi Y., Morimoto K., Shimomura S., Sato R., Hiraga N., Matsunaga

A., Zhou J.-R., Ohata T., Aki H., Sumoto K.,

Chem. Pharm. Bull., 66, 830-838 (2018).

10.1248/cpb.c18-00274

​

Preparation of Novel Bivalent Linker Mode Phenylboronic Acid Derivatives and Their Biological Evaluation

Furutachi M., Matsumoto A., Tamenaga T., Sugita A., Kuroiwa M., Yokomizo K., Zhou J.-R., Kashige N.,

Miake F., Sumoto K.,

Heterocycles, 96, 1088-1100 (2018).

10.3987/COM-18-13899

​

Novel Trivalent C3-Symmetrical Phenylboronic Acid Pinacol Esters and Their Biological Evaluation

Furutachi M., Fuchigami S., Ako K., Goto S., Gondo T., Takuse M., Yoshida M., Yokomizo K., Zhou J.-R.,

Matsunaga A., Hiraga N., Kashige N., Miake F., Sumoto K.,

Heterocycles, 96, 144-151 (2018).

10.3987/COM-17-13832

​

​

-2017-

​

Novel C2-Symmetrical Phenylboronic Acid Pinacol Esters with a Few Types of Linkers and Their Biological

Activities

Furutachi M., Gondo T., Goto S., Fuchigami S., Ako K., Oowada Y., Yokomizo K., Zhou J.-R., Ishizaki T.,

Koga T., Kashige N., Miake F., Sumoto K.,

Heterocycles, 94, 1748-1758 (2017).

10.3987/COM-17-13745

​

Antiviral Activities of Some New 2,4,6-Trisubstituted 1,3,5-Triazines Having Alkoxy and/or Alkylamino

Groups

Mibu N., Yokomizo K., Yuzuriha A., Otsubo M., Kawaguchi Y., Sano M., Sakai I., Nakayama K., Zhou J.-R.,

Sumoto K.,

Heterocycles, 94, 1653-1677 (2017).

10.3987/COM-17-13735

​

Novel Trivalent C3-Symmetrical Phenylboronic Acid Pinacol Esters

Furutachi M., Fuchigami S., Gondo T., Goto S., Ako K., Sumoto K.,

Org. Prep. Proced. Int., 49, 287-292 (2017).

10.1080/00304948.2017.1320929

​

Oxidative Aromatization and N-Oxidation of 1,2,3,4-Tetrahydroquinoline and -Isoquinoline Derivatives using

Sodium Tungstate in the Presence of Activated Carbon-molecular Oxygen

Tagawa Y., Inagaki M.,

Trend. Org. Chem., 18, 97-100 (2017).

Trend. Org. Chem.

​

Unique Physicochemical and Catalytic Properties Dictated by the B3NO2 Ring System

Noda H., Furutachi M., Asada Y., Shibasaki M., Kumagai N.,

Nat. Chem., 9, 571-577 (2017).

10.1038/nchem.2708

​

Catalytic Asymmetric Synthesis of the C1-C15 Segment of Spirastrellolide A

Sahara Y., Cui J., Furutachi M., Chen J., Watanabe T., Shibasaki M.,

Synthesis, 49, 69-75 (2017).

10.1055/s-0036-1588068

​

Preparation and Biological Activity of Novel Twin-drug Type C2-Symmetrical Cyclic Phenylboronic Acid

Derivatives

Furutachi M., Ejima A., Tsuru R., Goto S., Gondo T., Ako K., Fuchigami S., Fujii S., Okumura A., Tozuka A.,

Yokomizo K., Zhou J.-R., Inao H., Ono Y., Kashige N., Miake F., Sumoto K.,

Heterocycles, 95, 517-524 (2017).

10.3987/COM-16-S(S)9

​

​

-2016-

​

Antiviral Activity and Molecular Geometry of Some New Symmetrical Tris(aminoalkyl)amine Derivatives

Mibu N., Yokomizo K., Murakami K., Ono Y., Ishimaru M., Otsubo M., Inao H., Ono Y., Zhou J.-R., Sumoto

K.,

Chem. Pharm. Bull., 64, 1769-1780 (2016).

10.1248/cpb.c16-00682

​

Synthesis and Antibacterial Evaluation of Some New 5-Substituted Hydantoins and Novel Twin-drug Type

Derivatives

Furutachi M., Fujisaki F., Tsuru R., Ejima A., Gondo T., Goto S., Ito M., Nakamura M., Aki H., Kashige N.,

Miake F., Sumoto K.,

Heterocycles, 92, 1111-1120 (2016).

10.3987/COM-16-13453

​

Novel Twin-drug Type C2-Symmetrical Phenylboronic Acid Pinacol Esters

Furutachi M., Ejima A., Tsuru R., Goto S., Gondo T., Ako K., Fujii S., Okumura A., Tozuka A., Yokomizo K.,

Zhou J.-R., Inao H., Ono Y., Kashige N., Miake F., Sumoto K.,

Heterocycles, 92, 925-935 (2016).

10.3987/COM-16-13418

​

​

-2015-

​

Synthesis and Antiviral Evaluation of Some C3-Symmetrical Trialkoxy-substituted 1,3,5-Triazines and Their

Molecular Geometry

Mibu N., Yokomizo K., Aki H., Ota N., Fujii H., Yuzuriha A., Saneyoshi S., Tanaka A., Koga A., Zhou J.,

Miyata T., Sumoto K.,

Chem. Pharm. Bull., 63, 935-944 (2015).

10.1248/cpb.c15-00309

​

Preparation and Antibacterial Evaluation of Some Symmetrical Twin-drug Type Bivalent Molecules

Fujisaki F., Furutachi M., Fujiwara R., Okabe M., Aki H., Kashige N., Miake F., Sumoto K.,

Heterocycles, 91, 1668-1677 (2015).

10.3987/COM-15-13263

​

​

-2014-

​

Reaction of 5-Methylenehydantoins and Their Chemical Modification to Twin-drug Type Symmetrical

Molecules

Fujisaki F., Fujiwara R., Okabe M., Naito A., Fukami E., Aki H., Kashige N., Miake F., Sumoto K.,

Heterocycles, 89, 2745-2759 (2014).

 

Synthesis and Antiviral Activities of Some 2,4,6-Trisubstituted 1,3,5-Triazine Derivatives

Mibu N., Yokomizo K., Koga A., Honda M., Mizokami K., Fujii H., Ota N., Yuzuriha A., Ishimaru K., Zhou J.,

Miyata T., Sumoto K.,

Chem. Pharm. Bull., 62, 1032-1040 (2014).

 

Synthesis of New 5-Substituted Hydantoins and Symmetrical Twin-drug Type Hydantoin Derivatives

Fujisaki F., Aki H., Naito A., Fukami E., Kashige N., Miake F., Sumoto K.,

Chem. Pharm. Bull., 62, 429-438 (2014).

​

​

-2013-

​

Synthesis of Some New 5-Dialkylaminomethylhydantoins and Related Compounds

Fujisaki F., Egami M., Toyofuku K., Sumoto K.,

Heterocycles, 87, 133-145 (2013).

 

Carbohydrate Recognition of Symmetrical Tripodal Receptor Type Tris(2-aminoethyl)amine Derivatives

Mibu N., Aki H., Ikeda H., Saito A., Uchida W., Yokomizo K., Zhou J., Miyata T., Sumoto K.,

J. Therm. Anal. Calorim., 113, 1015-1018 (2013).

 

Synthesis, Chemical Properties, and Biological Evaluations of Some Twin-drug Type C2-Symmetrical

Derivatives

Fujisaki F., Usami H., Nakashima S., Nishida S., Fujiioka T., Kashige N., Miake F., Sumoto K.,

Heterocycles, 87, 665-675 (2013).

 

Synthesis and Antibacterial Activity of 3-(Substituted Arylmethyl)-4-acylaminomethyloxazolidin-2-ones and

Derivatization to Symmetrical Twin-drug Type Molecules

Fujisaki F., Hiromatsu S., Matsumura Y., Fukami A., Kashige N., Miake F., Sumoto K.,

J. Hetrocyclic Chem., 50, 417-424 (2013).

 

Synthesis and Biological Evaluation of Symmetrical 2,4,6-Trisubstituted 1,3,5-Triazine Derivatives

Mibu N., Yokomizo K., Takemura S., Ueki N., Itohara S., Zhou J., Miyata T., Sumoto K.,

Chem. Pharm. Bull., 61, 823-833 (2013).

 

Antibacterial Activity of Some 5-Dialkylaminomethylhydantoins and Related Derivatives

Fujisaki F., Toyofuku K., Egami M., Ishida S., Nakamoto N., Kashige N., Miake F., Sumoto K.,

Chem. Pharm. Bull., 61, 1090-1093 (2013).

​

​

-2012-

​

Molecular Symmetry and Biological Activities of New Symmetrical Tris(2-aminoethyl)amine Derivatives

Mibu N., Yokomizo K., Uchida W., Takemura S., Zhou J., Aki H., Miyata T., Sumoto K.,

Chem. Pharm. Bull., 60, 408-414 (2012).

​

​

-2011-

​

Synthesis of the Identical Linker Mode Twin-drug Type C2-Symmetrical Molecules

Fujisaki F., Usami H., Nakashima S., Iwashita S., Kurose Y., Kashige N., Miake F., Sumoto K.,

Heterocycles, 83, 1843-1851 (2011).

 

Synthesis of Caboxamycin and Its Derivatives using Eco-friendly Oxidation

Tagawa Y., Koba H., Tomoike K., Sumoto K.,

Heterocycles, 83, 867-874 (2011).

 

Synthesis and Biological Activities of Some N-Acyl-2,6-diaminopyridines and Related Linker Mode Identical

Twin Drugs

Mibu N., Yokomizo K., Saisho M., Oishi M., Aki H., Miyata T., Sumoto K.,

Heterocycles, 83, 385-393 (2011).

​

​

-2010-

​

Synthesis and Antiviral Activities of Some Heteroaryl-substituted Triarylmethanes

Mibu N., Yokomizo K., Miyata T., Sumoto K.,

J. Heterocyclic Chem., 47, 1434-1438 (2010).

 

Antibacterial Activity of 5-[(Dialkylamino)methyl]hydantoins and Related Compounds

Fujisaki F., Shoji K., Shimodouzono M., Kashige N., Miake F., Sumoto K.,

Chem. Pharm. Bull., 58, 1123-1126 (2010).

​

​

-2009-

​

Preparation and Chemical Properties of 5-Dialkylaminomethylhydantoins and 2-Thio-analogues

Fujisaki F., Shoji K., Sumoto K.,

Chem. Pharm. Bull., 57, 1415-1420 (2009).

 

A Synthetic Application of β-Aminoalanines to Some New 5-Dialkylaminomethyl-3-phenylhydantoin

Derivatives

Fujisaki F., Shoji K., Sumoto K.,

Heterocycles, 78, 213-220 (2009).